Two conditions, one lab, and a question medicine cannot answer yet.
There is no test for either condition, so people are not believed. There is no treatment, because nobody has proved yet what to aim one at. The Milano Project works on both, about equally.
A hair-loss and prostate drug taken by millions. For some people the effects do not stop when they stop taking it.
What Milano asks
Can what the drug changed be put back?
The project is testing a substance the body already makes, to see if it repairs what the drug changed.
If it does, there is something to try on patients. That is a treatment, not only an explanation.
One of the most prescribed antidepressants in the world. For some people the numbness does not stop when they stop taking it.
What Milano asks
Where does the numbness begin?
The project is looking in two places at once: the brain, and the nerves that carry feeling.
Find where it starts and you have somewhere to aim a treatment.
Your donation pays for the research that turns PFS and PSSD from a mystery into biology.
Every donation moves this forward.
1 out of 7 studies published
This study was done in rats.
So the gut and the brain are both affected in PFS. ALLO is now a treatment worth testing.
Results from the second study will be shared soon.
The most complete study programme ever done on these conditions.
Hard evidence that doctors and regulators can act on.
How finasteride and SSRIs affect allopregnanolone and other neurosteroids (hormones the brain makes).
Moving from lab work to treatment trials in people.
Open science, for every patient.
Robb travels to Italy to meet Professor Melcangi and his team. He goes inside the lab and meets the PhD students who run the tests. You hear from the scientists doing the work.
“This is not theory. It is science that is happening now.”
- Robb, SIDEfxHUB
The Milano team has worked on PFS and PSSD for over 10 years.
They did it quietly, for a community that had long been overlooked.
“We are no longer in the dark. The evidence is strong. The next step is human clinical trials.”
Two partners run their own PFS and PSSD research. You can support them directly.
Takes part in the Milano Project, led by Dr. Melcangi.
Offers the $100K RxISK Prize for a treatment breakthrough.
Learn more and donateBackground on the programme, what it is studying, and the patients pushing for answers.
PFS Research The Milano Project: A Potential Path to Treatment for PFS and PSSD Read more → 
PFS Research Understanding the Gut Microbiota Alterations in Post-Finasteride Syndrome (PFS) Patients Read more → PSSD Research The Similarities Between PFS and PSSD Read more → PFS Research Understanding the Genetic Factors Behind PFS Read more → 
Media Stories Team Melcangi Launches Milano Project to Advance PFS Research Read more → 
Media Stories Good Morning Britain: Robb Dixon Speaks Out About Post-Finasteride Syndrome Read more → Every donation pays for work that would not otherwise happen. This community has had to fight to be believed. Now it is funding the evidence.
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